{
 "schema": "lgasieve.cross-gene-reflex-reanalysis.v1",
 "created_utc": "2026-07-30T20:19:09.592294Z",
 "claims_boundary": [
  "BRCA2 anchors BRCA1 and BRCA1 anchors BRCA2; this is a two-gene fallback, not the broad-panel clinical model.",
  "Development libraries are presumed, not verified, negatives.",
  "Conditional spike-ins are internal software tests, not clinical sensitivity.",
  "Every candidate is REFLEX_POSITIVE and requires MLPA, aCGH, ddPCR, or another independently designed dosage assay.",
  "A simultaneous BRCA1/BRCA2 dosage shift remains non-identifiable."
 ],
 "inputs": {
  "matrix": {
   "path": "E:\\Geneseeq Dropbox\\Yang Shao\\Personal\\Codexhome\\Bioinformatics\\lga_research_2026\\project\\work\\exomedepth_development_v2\\fragment_counts.tsv",
   "sha256": "4c411785e92d17d7750e46b41b54cdcc6ce86a5cefcf24612b76639ed74fdbd0"
  },
  "partition": {
   "path": "E:\\Geneseeq Dropbox\\Yang Shao\\Personal\\Codexhome\\Bioinformatics\\lga_research_2026\\project\\work\\exomedepth_development_v2\\partition.json",
   "sha256": "693fdec2a3c71a880f4dd73221830fbecbfe8552a0e2c264c787ad9b984daa3f"
  },
  "n_samples": 147,
  "n_targets": 50,
  "n_usable_targets": 46,
  "excluded_targets": {
   "BRCA1": [
    "BRCA1_E23",
    "BRCA1_E11",
    "BRCA1_E01"
   ],
   "BRCA2": [
    "BRCA2_E01"
   ]
  },
  "evidence_directory": "E:\\Geneseeq Dropbox\\Yang Shao\\Personal\\Codexhome\\Bioinformatics\\lga_research_2026\\project\\validation_corrected\\evidence",
  "n_evidence_libraries": 150
 },
 "development_variants": [
  {
   "components": 0,
   "alpha": 0.05,
   "callable_targets": 25,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 1780,
    "positive_no_calls": 620,
    "sensitivity_completed": 0.15730337078651685,
    "negative_samples": 37,
    "negative_no_calls": 3,
    "false_reflex_samples": 0,
    "screen_specificity_completed": 1.0,
    "strata": {
     "class:single": {
      "completed": 333,
      "detected": 13,
      "sensitivity_completed": 0.03903903903903904
     },
     "class:whole_gene": {
      "completed": 24,
      "detected": 18,
      "sensitivity_completed": 0.75
     },
     "class:width_2": {
      "completed": 449,
      "detected": 37,
      "sensitivity_completed": 0.08240534521158129
     },
     "class:width_3": {
      "completed": 475,
      "detected": 70,
      "sensitivity_completed": 0.14736842105263157
     },
     "class:width_5": {
      "completed": 499,
      "detected": 142,
      "sensitivity_completed": 0.2845691382765531
     },
     "kind:DEL": {
      "completed": 918,
      "detected": 213,
      "sensitivity_completed": 0.23202614379084968
     },
     "kind:DUP": {
      "completed": 862,
      "detected": 67,
      "sensitivity_completed": 0.0777262180974478
     }
    }
   },
   "selection_utility": [
    1,
    0.15730337078651685,
    0.03903903903903904,
    1.0,
    0.5434782608695652
   ]
  },
  {
   "components": 0,
   "alpha": 0.1,
   "callable_targets": 25,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 1780,
    "positive_no_calls": 620,
    "sensitivity_completed": 0.15730337078651685,
    "negative_samples": 37,
    "negative_no_calls": 3,
    "false_reflex_samples": 0,
    "screen_specificity_completed": 1.0,
    "strata": {
     "class:single": {
      "completed": 333,
      "detected": 13,
      "sensitivity_completed": 0.03903903903903904
     },
     "class:whole_gene": {
      "completed": 24,
      "detected": 18,
      "sensitivity_completed": 0.75
     },
     "class:width_2": {
      "completed": 449,
      "detected": 37,
      "sensitivity_completed": 0.08240534521158129
     },
     "class:width_3": {
      "completed": 475,
      "detected": 70,
      "sensitivity_completed": 0.14736842105263157
     },
     "class:width_5": {
      "completed": 499,
      "detected": 142,
      "sensitivity_completed": 0.2845691382765531
     },
     "kind:DEL": {
      "completed": 918,
      "detected": 213,
      "sensitivity_completed": 0.23202614379084968
     },
     "kind:DUP": {
      "completed": 862,
      "detected": 67,
      "sensitivity_completed": 0.0777262180974478
     }
    }
   },
   "selection_utility": [
    1,
    0.15730337078651685,
    0.03903903903903904,
    1.0,
    0.5434782608695652
   ]
  },
  {
   "components": 0,
   "alpha": 0.2,
   "callable_targets": 25,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 1780,
    "positive_no_calls": 620,
    "sensitivity_completed": 0.37191011235955057,
    "negative_samples": 37,
    "negative_no_calls": 3,
    "false_reflex_samples": 7,
    "screen_specificity_completed": 0.7941176470588236,
    "strata": {
     "class:single": {
      "completed": 333,
      "detected": 50,
      "sensitivity_completed": 0.15015015015015015
     },
     "class:whole_gene": {
      "completed": 24,
      "detected": 21,
      "sensitivity_completed": 0.875
     },
     "class:width_2": {
      "completed": 449,
      "detected": 115,
      "sensitivity_completed": 0.2561247216035635
     },
     "class:width_3": {
      "completed": 475,
      "detected": 187,
      "sensitivity_completed": 0.3936842105263158
     },
     "class:width_5": {
      "completed": 499,
      "detected": 289,
      "sensitivity_completed": 0.5791583166332666
     },
     "kind:DEL": {
      "completed": 918,
      "detected": 454,
      "sensitivity_completed": 0.49455337690631807
     },
     "kind:DUP": {
      "completed": 862,
      "detected": 208,
      "sensitivity_completed": 0.24129930394431554
     }
    }
   },
   "selection_utility": [
    0,
    0.37191011235955057,
    0.15015015015015015,
    0.7941176470588236,
    0.5434782608695652
   ]
  },
  {
   "components": 2,
   "alpha": 0.05,
   "callable_targets": 44,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2291,
    "positive_no_calls": 109,
    "sensitivity_completed": 0.25491051942383236,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 1,
    "screen_specificity_completed": 0.972972972972973,
    "strata": {
     "class:single": {
      "completed": 588,
      "detected": 47,
      "sensitivity_completed": 0.07993197278911565
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 23,
      "sensitivity_completed": 0.8846153846153846
     },
     "class:width_2": {
      "completed": 593,
      "detected": 118,
      "sensitivity_completed": 0.19898819561551434
     },
     "class:width_3": {
      "completed": 547,
      "detected": 169,
      "sensitivity_completed": 0.30895795246800734
     },
     "class:width_5": {
      "completed": 537,
      "detected": 227,
      "sensitivity_completed": 0.4227188081936685
     },
     "kind:DEL": {
      "completed": 1172,
      "detected": 473,
      "sensitivity_completed": 0.4035836177474403
     },
     "kind:DUP": {
      "completed": 1119,
      "detected": 111,
      "sensitivity_completed": 0.09919571045576407
     }
    }
   },
   "selection_utility": [
    2,
    0.25491051942383236,
    0.07993197278911565,
    0.972972972972973,
    0.9565217391304348
   ]
  },
  {
   "components": 2,
   "alpha": 0.1,
   "callable_targets": 44,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2291,
    "positive_no_calls": 109,
    "sensitivity_completed": 0.25491051942383236,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 1,
    "screen_specificity_completed": 0.972972972972973,
    "strata": {
     "class:single": {
      "completed": 588,
      "detected": 47,
      "sensitivity_completed": 0.07993197278911565
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 23,
      "sensitivity_completed": 0.8846153846153846
     },
     "class:width_2": {
      "completed": 593,
      "detected": 118,
      "sensitivity_completed": 0.19898819561551434
     },
     "class:width_3": {
      "completed": 547,
      "detected": 169,
      "sensitivity_completed": 0.30895795246800734
     },
     "class:width_5": {
      "completed": 537,
      "detected": 227,
      "sensitivity_completed": 0.4227188081936685
     },
     "kind:DEL": {
      "completed": 1172,
      "detected": 473,
      "sensitivity_completed": 0.4035836177474403
     },
     "kind:DUP": {
      "completed": 1119,
      "detected": 111,
      "sensitivity_completed": 0.09919571045576407
     }
    }
   },
   "selection_utility": [
    2,
    0.25491051942383236,
    0.07993197278911565,
    0.972972972972973,
    0.9565217391304348
   ]
  },
  {
   "components": 2,
   "alpha": 0.2,
   "callable_targets": 44,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2291,
    "positive_no_calls": 109,
    "sensitivity_completed": 0.43037974683544306,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 6,
    "screen_specificity_completed": 0.8378378378378378,
    "strata": {
     "class:single": {
      "completed": 588,
      "detected": 133,
      "sensitivity_completed": 0.2261904761904762
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 25,
      "sensitivity_completed": 0.9615384615384616
     },
     "class:width_2": {
      "completed": 593,
      "detected": 261,
      "sensitivity_completed": 0.44013490725126475
     },
     "class:width_3": {
      "completed": 547,
      "detected": 265,
      "sensitivity_completed": 0.4844606946983547
     },
     "class:width_5": {
      "completed": 537,
      "detected": 302,
      "sensitivity_completed": 0.5623836126629422
     },
     "kind:DEL": {
      "completed": 1172,
      "detected": 713,
      "sensitivity_completed": 0.6083617747440273
     },
     "kind:DUP": {
      "completed": 1119,
      "detected": 273,
      "sensitivity_completed": 0.24396782841823056
     }
    }
   },
   "selection_utility": [
    1,
    0.43037974683544306,
    0.2261904761904762,
    0.8378378378378378,
    0.9565217391304348
   ]
  },
  {
   "components": 4,
   "alpha": 0.05,
   "callable_targets": 46,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2345,
    "positive_no_calls": 55,
    "sensitivity_completed": 0.4878464818763326,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 4,
    "screen_specificity_completed": 0.8918918918918919,
    "strata": {
     "class:single": {
      "completed": 614,
      "detected": 158,
      "sensitivity_completed": 0.25732899022801303
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 26,
      "sensitivity_completed": 1.0
     },
     "class:width_2": {
      "completed": 612,
      "detected": 311,
      "sensitivity_completed": 0.5081699346405228
     },
     "class:width_3": {
      "completed": 556,
      "detected": 291,
      "sensitivity_completed": 0.5233812949640287
     },
     "class:width_5": {
      "completed": 537,
      "detected": 358,
      "sensitivity_completed": 0.6666666666666666
     },
     "kind:DEL": {
      "completed": 1200,
      "detected": 812,
      "sensitivity_completed": 0.6766666666666666
     },
     "kind:DUP": {
      "completed": 1145,
      "detected": 332,
      "sensitivity_completed": 0.28995633187772923
     }
    }
   },
   "selection_utility": [
    1,
    0.4878464818763326,
    0.25732899022801303,
    0.8918918918918919,
    1.0
   ]
  },
  {
   "components": 4,
   "alpha": 0.1,
   "callable_targets": 46,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2345,
    "positive_no_calls": 55,
    "sensitivity_completed": 0.4878464818763326,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 4,
    "screen_specificity_completed": 0.8918918918918919,
    "strata": {
     "class:single": {
      "completed": 614,
      "detected": 158,
      "sensitivity_completed": 0.25732899022801303
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 26,
      "sensitivity_completed": 1.0
     },
     "class:width_2": {
      "completed": 612,
      "detected": 311,
      "sensitivity_completed": 0.5081699346405228
     },
     "class:width_3": {
      "completed": 556,
      "detected": 291,
      "sensitivity_completed": 0.5233812949640287
     },
     "class:width_5": {
      "completed": 537,
      "detected": 358,
      "sensitivity_completed": 0.6666666666666666
     },
     "kind:DEL": {
      "completed": 1200,
      "detected": 812,
      "sensitivity_completed": 0.6766666666666666
     },
     "kind:DUP": {
      "completed": 1145,
      "detected": 332,
      "sensitivity_completed": 0.28995633187772923
     }
    }
   },
   "selection_utility": [
    1,
    0.4878464818763326,
    0.25732899022801303,
    0.8918918918918919,
    1.0
   ]
  },
  {
   "components": 4,
   "alpha": 0.2,
   "callable_targets": 46,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2345,
    "positive_no_calls": 55,
    "sensitivity_completed": 0.5705756929637527,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 7,
    "screen_specificity_completed": 0.8108108108108107,
    "strata": {
     "class:single": {
      "completed": 614,
      "detected": 224,
      "sensitivity_completed": 0.36482084690553745
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 26,
      "sensitivity_completed": 1.0
     },
     "class:width_2": {
      "completed": 612,
      "detected": 357,
      "sensitivity_completed": 0.5833333333333334
     },
     "class:width_3": {
      "completed": 556,
      "detected": 332,
      "sensitivity_completed": 0.5971223021582733
     },
     "class:width_5": {
      "completed": 537,
      "detected": 399,
      "sensitivity_completed": 0.7430167597765364
     },
     "kind:DEL": {
      "completed": 1200,
      "detected": 895,
      "sensitivity_completed": 0.7458333333333333
     },
     "kind:DUP": {
      "completed": 1145,
      "detected": 443,
      "sensitivity_completed": 0.3868995633187773
     }
    }
   },
   "selection_utility": [
    1,
    0.5705756929637527,
    0.36482084690553745,
    0.8108108108108107,
    1.0
   ]
  },
  {
   "components": 6,
   "alpha": 0.05,
   "callable_targets": 46,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2345,
    "positive_no_calls": 55,
    "sensitivity_completed": 0.5360341151385928,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 2,
    "screen_specificity_completed": 0.9459459459459459,
    "strata": {
     "class:single": {
      "completed": 614,
      "detected": 167,
      "sensitivity_completed": 0.2719869706840391
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 26,
      "sensitivity_completed": 1.0
     },
     "class:width_2": {
      "completed": 612,
      "detected": 326,
      "sensitivity_completed": 0.5326797385620915
     },
     "class:width_3": {
      "completed": 556,
      "detected": 342,
      "sensitivity_completed": 0.6151079136690647
     },
     "class:width_5": {
      "completed": 537,
      "detected": 396,
      "sensitivity_completed": 0.7374301675977654
     },
     "kind:DEL": {
      "completed": 1200,
      "detected": 879,
      "sensitivity_completed": 0.7325
     },
     "kind:DUP": {
      "completed": 1145,
      "detected": 378,
      "sensitivity_completed": 0.33013100436681225
     }
    }
   },
   "selection_utility": [
    2,
    0.5360341151385928,
    0.2719869706840391,
    0.9459459459459459,
    1.0
   ]
  },
  {
   "components": 6,
   "alpha": 0.1,
   "callable_targets": 46,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2345,
    "positive_no_calls": 55,
    "sensitivity_completed": 0.5360341151385928,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 2,
    "screen_specificity_completed": 0.9459459459459459,
    "strata": {
     "class:single": {
      "completed": 614,
      "detected": 167,
      "sensitivity_completed": 0.2719869706840391
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 26,
      "sensitivity_completed": 1.0
     },
     "class:width_2": {
      "completed": 612,
      "detected": 326,
      "sensitivity_completed": 0.5326797385620915
     },
     "class:width_3": {
      "completed": 556,
      "detected": 342,
      "sensitivity_completed": 0.6151079136690647
     },
     "class:width_5": {
      "completed": 537,
      "detected": 396,
      "sensitivity_completed": 0.7374301675977654
     },
     "kind:DEL": {
      "completed": 1200,
      "detected": 879,
      "sensitivity_completed": 0.7325
     },
     "kind:DUP": {
      "completed": 1145,
      "detected": 378,
      "sensitivity_completed": 0.33013100436681225
     }
    }
   },
   "selection_utility": [
    2,
    0.5360341151385928,
    0.2719869706840391,
    0.9459459459459459,
    1.0
   ]
  },
  {
   "components": 6,
   "alpha": 0.2,
   "callable_targets": 46,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2345,
    "positive_no_calls": 55,
    "sensitivity_completed": 0.6742004264392324,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 9,
    "screen_specificity_completed": 0.7567567567567568,
    "strata": {
     "class:single": {
      "completed": 614,
      "detected": 266,
      "sensitivity_completed": 0.43322475570032576
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 26,
      "sensitivity_completed": 1.0
     },
     "class:width_2": {
      "completed": 612,
      "detected": 418,
      "sensitivity_completed": 0.6830065359477124
     },
     "class:width_3": {
      "completed": 556,
      "detected": 421,
      "sensitivity_completed": 0.7571942446043165
     },
     "class:width_5": {
      "completed": 537,
      "detected": 450,
      "sensitivity_completed": 0.8379888268156425
     },
     "kind:DEL": {
      "completed": 1200,
      "detected": 1012,
      "sensitivity_completed": 0.8433333333333334
     },
     "kind:DUP": {
      "completed": 1145,
      "detected": 569,
      "sensitivity_completed": 0.496943231441048
     }
    }
   },
   "selection_utility": [
    1,
    0.6742004264392324,
    0.43322475570032576,
    0.7567567567567568,
    1.0
   ]
  },
  {
   "components": 8,
   "alpha": 0.05,
   "callable_targets": 46,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2345,
    "positive_no_calls": 55,
    "sensitivity_completed": 0.6443496801705757,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 3,
    "screen_specificity_completed": 0.9189189189189189,
    "strata": {
     "class:single": {
      "completed": 614,
      "detected": 218,
      "sensitivity_completed": 0.3550488599348534
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 26,
      "sensitivity_completed": 1.0
     },
     "class:width_2": {
      "completed": 612,
      "detected": 397,
      "sensitivity_completed": 0.6486928104575164
     },
     "class:width_3": {
      "completed": 556,
      "detected": 421,
      "sensitivity_completed": 0.7571942446043165
     },
     "class:width_5": {
      "completed": 537,
      "detected": 449,
      "sensitivity_completed": 0.8361266294227188
     },
     "kind:DEL": {
      "completed": 1200,
      "detected": 1003,
      "sensitivity_completed": 0.8358333333333333
     },
     "kind:DUP": {
      "completed": 1145,
      "detected": 508,
      "sensitivity_completed": 0.44366812227074237
     }
    }
   },
   "selection_utility": [
    2,
    0.6443496801705757,
    0.3550488599348534,
    0.9189189189189189,
    1.0
   ]
  },
  {
   "components": 8,
   "alpha": 0.1,
   "callable_targets": 46,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2345,
    "positive_no_calls": 55,
    "sensitivity_completed": 0.6443496801705757,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 3,
    "screen_specificity_completed": 0.9189189189189189,
    "strata": {
     "class:single": {
      "completed": 614,
      "detected": 218,
      "sensitivity_completed": 0.3550488599348534
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 26,
      "sensitivity_completed": 1.0
     },
     "class:width_2": {
      "completed": 612,
      "detected": 397,
      "sensitivity_completed": 0.6486928104575164
     },
     "class:width_3": {
      "completed": 556,
      "detected": 421,
      "sensitivity_completed": 0.7571942446043165
     },
     "class:width_5": {
      "completed": 537,
      "detected": 449,
      "sensitivity_completed": 0.8361266294227188
     },
     "kind:DEL": {
      "completed": 1200,
      "detected": 1003,
      "sensitivity_completed": 0.8358333333333333
     },
     "kind:DUP": {
      "completed": 1145,
      "detected": 508,
      "sensitivity_completed": 0.44366812227074237
     }
    }
   },
   "selection_utility": [
    2,
    0.6443496801705757,
    0.3550488599348534,
    0.9189189189189189,
    1.0
   ]
  },
  {
   "components": 8,
   "alpha": 0.2,
   "callable_targets": 46,
   "metrics": {
    "positive_spike_ins": 2400,
    "positive_completed": 2345,
    "positive_no_calls": 55,
    "sensitivity_completed": 0.726226012793177,
    "negative_samples": 37,
    "negative_no_calls": 0,
    "false_reflex_samples": 12,
    "screen_specificity_completed": 0.6756756756756757,
    "strata": {
     "class:single": {
      "completed": 614,
      "detected": 312,
      "sensitivity_completed": 0.50814332247557
     },
     "class:whole_gene": {
      "completed": 26,
      "detected": 26,
      "sensitivity_completed": 1.0
     },
     "class:width_2": {
      "completed": 612,
      "detected": 461,
      "sensitivity_completed": 0.7532679738562091
     },
     "class:width_3": {
      "completed": 556,
      "detected": 442,
      "sensitivity_completed": 0.7949640287769785
     },
     "class:width_5": {
      "completed": 537,
      "detected": 462,
      "sensitivity_completed": 0.8603351955307262
     },
     "kind:DEL": {
      "completed": 1200,
      "detected": 1072,
      "sensitivity_completed": 0.8933333333333333
     },
     "kind:DUP": {
      "completed": 1145,
      "detected": 631,
      "sensitivity_completed": 0.5510917030567686
     }
    }
   },
   "selection_utility": [
    1,
    0.726226012793177,
    0.50814332247557,
    0.6756756756756757,
    1.0
   ]
  }
 ],
 "selected": {
  "components": 8,
  "alpha": 0.05,
  "callable_targets": 46,
  "metrics": {
   "positive_spike_ins": 2400,
   "positive_completed": 2345,
   "positive_no_calls": 55,
   "sensitivity_completed": 0.6443496801705757,
   "negative_samples": 37,
   "negative_no_calls": 0,
   "false_reflex_samples": 3,
   "screen_specificity_completed": 0.9189189189189189,
   "strata": {
    "class:single": {
     "completed": 614,
     "detected": 218,
     "sensitivity_completed": 0.3550488599348534
    },
    "class:whole_gene": {
     "completed": 26,
     "detected": 26,
     "sensitivity_completed": 1.0
    },
    "class:width_2": {
     "completed": 612,
     "detected": 397,
     "sensitivity_completed": 0.6486928104575164
    },
    "class:width_3": {
     "completed": 556,
     "detected": 421,
     "sensitivity_completed": 0.7571942446043165
    },
    "class:width_5": {
     "completed": 537,
     "detected": 449,
     "sensitivity_completed": 0.8361266294227188
    },
    "kind:DEL": {
     "completed": 1200,
     "detected": 1003,
     "sensitivity_completed": 0.8358333333333333
    },
    "kind:DUP": {
     "completed": 1145,
     "detected": 508,
     "sensitivity_completed": 0.44366812227074237
    }
   }
  },
  "selection_utility": [
   2,
   0.6443496801705757,
   0.3550488599348534,
   0.9189189189189189,
   1.0
  ]
 },
 "models": {
  "BRCA1": {
   "path": "E:\\Geneseeq Dropbox\\Yang Shao\\Personal\\Codexhome\\Bioinformatics\\lga_research_2026\\project\\analysis\\cross_gene_reflex_model_brca1.json",
   "sha256": "a86427a7626b65e8cd28a5ea4d8d4fec83505b5953a03d9fec13e23eea8df524"
  },
  "BRCA2": {
   "path": "E:\\Geneseeq Dropbox\\Yang Shao\\Personal\\Codexhome\\Bioinformatics\\lga_research_2026\\project\\analysis\\cross_gene_reflex_model_brca2.json",
   "sha256": "a1ecf5f3056ee0505cfc960b534ad2524f75090c756f18d346c9e4490ef0f63a"
  }
 },
 "operational_status_counts": {
  "INCOMPLETE_SCREEN": 141,
  "REFLEX_POSITIVE": 6
 },
 "operational_results": [
  {
   "sample": "HG00116",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00117",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA1",
     "kind": "DEL",
     "first_exon": "7",
     "last_exon": "9",
     "target_ids": [
      "BRCA1_E07",
      "BRCA1_E08",
      "BRCA1_E09"
     ],
     "n_targets": 3,
     "mean_log2": -0.5979,
     "statistic": 4.049,
     "threshold": 3.8026,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00132",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00149",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00150",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00243",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00271",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00275",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00306",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00376",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00473",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00593",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00693",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG00708",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01052",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01107",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01113",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01130",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01139",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01173",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01271",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01280",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01334",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01345",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01384",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01461",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01464",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01578",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01596",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01608",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01618",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01632",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01670",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01802",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01840",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01841",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01869",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01870",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01885",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01923",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01924",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01942",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01950",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01982",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG01988",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02061",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02069",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02154",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02187",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02235",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02252",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02266",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02292",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02307",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02312",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02317",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA1",
     "kind": "DEL",
     "first_exon": "20",
     "last_exon": "22",
     "target_ids": [
      "BRCA1_E20",
      "BRCA1_E21",
      "BRCA1_E22"
     ],
     "n_targets": 3,
     "mean_log2": -0.6525,
     "statistic": 3.9983,
     "threshold": 3.8026,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02360",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02386",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02389",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02521",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02561",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02580",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02601",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02610",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02757",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02768",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02775",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02804",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02811",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG02944",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03085",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03091",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03130",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03169",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03238",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03246",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03258",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03401",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03442",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03594",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03595",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03640",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03646",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03660",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03698",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03744",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03750",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA1",
     "kind": "DEL",
     "first_exon": "16",
     "last_exon": "17",
     "target_ids": [
      "BRCA1_E16",
      "BRCA1_E17"
     ],
     "n_targets": 2,
     "mean_log2": -0.6151,
     "statistic": 4.0972,
     "threshold": 3.6242,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03767",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03785",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03800",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03833",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03897",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03920",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03943",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03949",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG03953",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG04158",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "HG04194",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA12275",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA12776",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA12829",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA18502",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA18552",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA18573",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA18609",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA18611",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA18632",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA18643",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA18645",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA2",
     "kind": "DEL",
     "first_exon": "8",
     "last_exon": "17",
     "target_ids": [
      "BRCA2_E08",
      "BRCA2_E09",
      "BRCA2_E10",
      "BRCA2_E11",
      "BRCA2_E12",
      "BRCA2_E13",
      "BRCA2_E14",
      "BRCA2_E15",
      "BRCA2_E16",
      "BRCA2_E17"
     ],
     "n_targets": 10,
     "mean_log2": -0.4365,
     "statistic": 5.8404,
     "threshold": 3.9406,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA18971",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA18972",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19000",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19003",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19091",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19096",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19131",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19153",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19172",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19395",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19446",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19474",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19678",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19704",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19726",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19728",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19749",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19758",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19759",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19761",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA19762",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20346",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20520",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20529",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20530",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA1",
     "kind": "DUP",
     "first_exon": "15",
     "last_exon": "22",
     "target_ids": [
      "BRCA1_E15",
      "BRCA1_E16",
      "BRCA1_E17",
      "BRCA1_E18",
      "BRCA1_E19",
      "BRCA1_E20",
      "BRCA1_E21",
      "BRCA1_E22"
     ],
     "n_targets": 8,
     "mean_log2": 0.5238,
     "statistic": 4.8628,
     "threshold": 4.0354,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20534",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20538",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20539",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20799",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20813",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20821",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20854",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20869",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA20904",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA21108",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA21120",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA2",
     "kind": "DEL",
     "first_exon": "13",
     "last_exon": "13",
     "target_ids": [
      "BRCA2_E13"
     ],
     "n_targets": 1,
     "mean_log2": -2.3854,
     "statistic": 6.0606,
     "threshold": 4.8399,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA21129",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  },
  {
   "sample": "NA21137",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": []
  }
 ],
 "evidence_operational_status_counts": {
  "INCOMPLETE_SCREEN": 141,
  "REFLEX_POSITIVE": 6,
  "NO_CALL_QC": 3
 },
 "evidence_operational_results": [
  {
   "sample": "HG00116",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 75.9
  },
  {
   "sample": "HG00117",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA1",
     "kind": "DEL",
     "first_exon": "7",
     "last_exon": "9",
     "target_ids": [
      "BRCA1_E07",
      "BRCA1_E08",
      "BRCA1_E09"
     ],
     "n_targets": 3,
     "mean_log2": -0.5979,
     "statistic": 4.049,
     "threshold": 3.8026,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 41.3
  },
  {
   "sample": "HG00132",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 47.2
  },
  {
   "sample": "HG00149",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 48.5
  },
  {
   "sample": "HG00150",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 54.9
  },
  {
   "sample": "HG00243",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 71.9
  },
  {
   "sample": "HG00271",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 126.1
  },
  {
   "sample": "HG00275",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 105.1
  },
  {
   "sample": "HG00306",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 37.8
  },
  {
   "sample": "HG00376",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 91.5
  },
  {
   "sample": "HG00473",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 60.1
  },
  {
   "sample": "HG00593",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 67.6
  },
  {
   "sample": "HG00693",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 123.3
  },
  {
   "sample": "HG00708",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 114.4
  },
  {
   "sample": "HG01052",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 129.5
  },
  {
   "sample": "HG01107",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 150.1
  },
  {
   "sample": "HG01113",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 96.9
  },
  {
   "sample": "HG01130",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 121.1
  },
  {
   "sample": "HG01139",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 55.8
  },
  {
   "sample": "HG01173",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 111.7
  },
  {
   "sample": "HG01271",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 62.0
  },
  {
   "sample": "HG01280",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 86.9
  },
  {
   "sample": "HG01334",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 97.7
  },
  {
   "sample": "HG01345",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 54.5
  },
  {
   "sample": "HG01384",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 48.6
  },
  {
   "sample": "HG01461",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 32.4
  },
  {
   "sample": "HG01464",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 34.6
  },
  {
   "sample": "HG01578",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 135.5
  },
  {
   "sample": "HG01596",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 127.6
  },
  {
   "sample": "HG01608",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 58.5
  },
  {
   "sample": "HG01618",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 65.6
  },
  {
   "sample": "HG01632",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 155.6
  },
  {
   "sample": "HG01670",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 47.9
  },
  {
   "sample": "HG01802",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 127.3
  },
  {
   "sample": "HG01840",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 143.2
  },
  {
   "sample": "HG01841",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 126.5
  },
  {
   "sample": "HG01869",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 70.2
  },
  {
   "sample": "HG01870",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 261.0
  },
  {
   "sample": "HG01885",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 68.9
  },
  {
   "sample": "HG01923",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 134.6
  },
  {
   "sample": "HG01924",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 109.4
  },
  {
   "sample": "HG01942",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 65.0
  },
  {
   "sample": "HG01950",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 58.7
  },
  {
   "sample": "HG01982",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 141.6
  },
  {
   "sample": "HG01988",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 64.5
  },
  {
   "sample": "HG02061",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 138.9
  },
  {
   "sample": "HG02069",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 264.0
  },
  {
   "sample": "HG02154",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 65.1
  },
  {
   "sample": "HG02187",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 35.7
  },
  {
   "sample": "HG02235",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 49.4
  },
  {
   "sample": "HG02252",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 116.3
  },
  {
   "sample": "HG02266",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 52.5
  },
  {
   "sample": "HG02292",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 129.0
  },
  {
   "sample": "HG02307",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 50.9
  },
  {
   "sample": "HG02312",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 33.0
  },
  {
   "sample": "HG02317",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA1",
     "kind": "DEL",
     "first_exon": "20",
     "last_exon": "22",
     "target_ids": [
      "BRCA1_E20",
      "BRCA1_E21",
      "BRCA1_E22"
     ],
     "n_targets": 3,
     "mean_log2": -0.6525,
     "statistic": 3.9983,
     "threshold": 3.8026,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 67.6
  },
  {
   "sample": "HG02360",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 119.2
  },
  {
   "sample": "HG02386",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 141.1
  },
  {
   "sample": "HG02389",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 118.3
  },
  {
   "sample": "HG02521",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 54.6
  },
  {
   "sample": "HG02561",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 62.8
  },
  {
   "sample": "HG02580",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 118.4
  },
  {
   "sample": "HG02601",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 41.5
  },
  {
   "sample": "HG02610",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 67.3
  },
  {
   "sample": "HG02757",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 64.5
  },
  {
   "sample": "HG02768",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 47.0
  },
  {
   "sample": "HG02775",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 124.3
  },
  {
   "sample": "HG02804",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 75.2
  },
  {
   "sample": "HG02811",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 58.3
  },
  {
   "sample": "HG02944",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 66.5
  },
  {
   "sample": "HG03022",
   "status": "NO_CALL_QC",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [
    "source median target depth 24.1 is below 30.0"
   ],
   "source_median_target_depth": 24.1
  },
  {
   "sample": "HG03085",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 51.5
  },
  {
   "sample": "HG03091",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 66.2
  },
  {
   "sample": "HG03130",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 41.8
  },
  {
   "sample": "HG03169",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 40.2
  },
  {
   "sample": "HG03238",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 132.6
  },
  {
   "sample": "HG03246",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 38.9
  },
  {
   "sample": "HG03258",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 75.5
  },
  {
   "sample": "HG03401",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 72.9
  },
  {
   "sample": "HG03442",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 94.4
  },
  {
   "sample": "HG03594",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 85.2
  },
  {
   "sample": "HG03595",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 135.6
  },
  {
   "sample": "HG03640",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 33.6
  },
  {
   "sample": "HG03646",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 130.4
  },
  {
   "sample": "HG03660",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 55.7
  },
  {
   "sample": "HG03698",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 104.9
  },
  {
   "sample": "HG03744",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 78.2
  },
  {
   "sample": "HG03750",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA1",
     "kind": "DEL",
     "first_exon": "16",
     "last_exon": "17",
     "target_ids": [
      "BRCA1_E16",
      "BRCA1_E17"
     ],
     "n_targets": 2,
     "mean_log2": -0.6151,
     "statistic": 4.0972,
     "threshold": 3.6242,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 46.2
  },
  {
   "sample": "HG03767",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 41.1
  },
  {
   "sample": "HG03785",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 129.4
  },
  {
   "sample": "HG03800",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 58.2
  },
  {
   "sample": "HG03833",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 171.5
  },
  {
   "sample": "HG03897",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 53.5
  },
  {
   "sample": "HG03920",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 148.4
  },
  {
   "sample": "HG03943",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 54.0
  },
  {
   "sample": "HG03949",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 44.9
  },
  {
   "sample": "HG03953",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 63.8
  },
  {
   "sample": "HG04158",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 38.7
  },
  {
   "sample": "HG04194",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 137.9
  },
  {
   "sample": "NA12156",
   "status": "NO_CALL_QC",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [
    "source median target depth 29.3 is below 30.0"
   ],
   "source_median_target_depth": 29.3
  },
  {
   "sample": "NA12275",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 85.0
  },
  {
   "sample": "NA12342",
   "status": "NO_CALL_QC",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [
    "source median target depth 28.6 is below 30.0"
   ],
   "source_median_target_depth": 28.6
  },
  {
   "sample": "NA12776",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 174.1
  },
  {
   "sample": "NA12829",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 90.5
  },
  {
   "sample": "NA18502",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 35.3
  },
  {
   "sample": "NA18552",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 108.3
  },
  {
   "sample": "NA18573",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 89.5
  },
  {
   "sample": "NA18609",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 116.9
  },
  {
   "sample": "NA18611",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 120.3
  },
  {
   "sample": "NA18632",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 46.5
  },
  {
   "sample": "NA18643",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 70.9
  },
  {
   "sample": "NA18645",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA2",
     "kind": "DEL",
     "first_exon": "8",
     "last_exon": "17",
     "target_ids": [
      "BRCA2_E08",
      "BRCA2_E09",
      "BRCA2_E10",
      "BRCA2_E11",
      "BRCA2_E12",
      "BRCA2_E13",
      "BRCA2_E14",
      "BRCA2_E15",
      "BRCA2_E16",
      "BRCA2_E17"
     ],
     "n_targets": 10,
     "mean_log2": -0.4365,
     "statistic": 5.8404,
     "threshold": 3.9406,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 34.2
  },
  {
   "sample": "NA18971",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 110.3
  },
  {
   "sample": "NA18972",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 80.6
  },
  {
   "sample": "NA19000",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 118.3
  },
  {
   "sample": "NA19003",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 86.2
  },
  {
   "sample": "NA19091",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 84.3
  },
  {
   "sample": "NA19096",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 68.3
  },
  {
   "sample": "NA19131",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 89.2
  },
  {
   "sample": "NA19153",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 93.5
  },
  {
   "sample": "NA19172",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 123.2
  },
  {
   "sample": "NA19395",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 46.0
  },
  {
   "sample": "NA19446",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 70.0
  },
  {
   "sample": "NA19474",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 118.2
  },
  {
   "sample": "NA19678",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 32.7
  },
  {
   "sample": "NA19704",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 33.4
  },
  {
   "sample": "NA19726",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 31.9
  },
  {
   "sample": "NA19728",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 99.4
  },
  {
   "sample": "NA19749",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 86.0
  },
  {
   "sample": "NA19758",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 95.6
  },
  {
   "sample": "NA19759",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 107.8
  },
  {
   "sample": "NA19761",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 77.3
  },
  {
   "sample": "NA19762",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 82.9
  },
  {
   "sample": "NA20346",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 81.1
  },
  {
   "sample": "NA20520",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 59.1
  },
  {
   "sample": "NA20529",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 56.7
  },
  {
   "sample": "NA20530",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA1",
     "kind": "DUP",
     "first_exon": "15",
     "last_exon": "22",
     "target_ids": [
      "BRCA1_E15",
      "BRCA1_E16",
      "BRCA1_E17",
      "BRCA1_E18",
      "BRCA1_E19",
      "BRCA1_E20",
      "BRCA1_E21",
      "BRCA1_E22"
     ],
     "n_targets": 8,
     "mean_log2": 0.5238,
     "statistic": 4.8628,
     "threshold": 4.0354,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 50.0
  },
  {
   "sample": "NA20534",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 44.7
  },
  {
   "sample": "NA20538",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 80.1
  },
  {
   "sample": "NA20539",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 34.5
  },
  {
   "sample": "NA20799",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 60.3
  },
  {
   "sample": "NA20813",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 81.8
  },
  {
   "sample": "NA20821",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 99.5
  },
  {
   "sample": "NA20854",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 66.7
  },
  {
   "sample": "NA20869",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 60.9
  },
  {
   "sample": "NA20904",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 67.2
  },
  {
   "sample": "NA21108",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 67.3
  },
  {
   "sample": "NA21120",
   "status": "REFLEX_POSITIVE",
   "calls": [
    {
     "gene": "BRCA2",
     "kind": "DEL",
     "first_exon": "13",
     "last_exon": "13",
     "target_ids": [
      "BRCA2_E13"
     ],
     "n_targets": 1,
     "mean_log2": -2.3854,
     "statistic": 6.0606,
     "threshold": 4.8399,
     "disposition": "REFLEX_POSITIVE"
    }
   ],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 32.6
  },
  {
   "sample": "NA21129",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 35.5
  },
  {
   "sample": "NA21137",
   "status": "INCOMPLETE_SCREEN",
   "calls": [],
   "excluded_targets": [
    "BRCA1_E01",
    "BRCA1_E11",
    "BRCA1_E23",
    "BRCA2_E01"
   ],
   "reasons": [],
   "source_median_target_depth": 69.5
  }
 ],
 "environment": {
  "python": "3.14.6",
  "numpy": "2.5.1"
 }
}
